Expression And Activity Of Matrix Metalloproteinases In Leukemia

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Novel MMP-9 Substrates in Cancer Cells Revealed by a Label

by D Xu 2008 Cited by 163 (amyloid- precursor protein, collagen VI, leukemia inhib- itory factor the ability to reduce the expression and activity of MMP-9 in the. PC-3ML cell line.

Matrix Metalloproteinase 9 Facilitates Hepatitis B Virus

25 Jan 2017 and HBV stimulates MMP-9 expression in macrophages and PBMCs isolated from antiviral activity against RSV by enhancing neutrophil recruitment to from human acute monocytic leukemia cells (THP-1) were incubated 

Matrix metalloproteinases in tuberculosis - European

phenotype in TB in which MMP activity was not balanced by the specific tissue macrophages but they are derived from leukaemia cells [30] and consequently Matrix metalloproteinases (MMPs) are expressed in human tuberculosis (TB) 

PDF 720.87 K - Asian Pacific Journal of Cancer Prevention

by AK Chaudhary 2016 Cited by 7 The expression and activity of MMPs in a variety of human cancers have Keywords: Matrix metalloproteinases - tumorigenesis - MMP inhibitors - leukemias.

Matrix Metalloproteinase-9 and Cell Division in

regulation of MMP activity in vivo.2 The matrix undergoes intense remodeling during with lymphoma cells constitutively expressing MMP-9 de- velop thymic ney murine leukemia virus reverse transcriptase RNase H minus point mutant 

Matrix Metalloproteinase Production by Bone Marrow

by C Ries 1999 Cited by 141 Under physiological conditions, MMP expression, secretion, and activity are leukemia; CML, chronic myeloid leukemia; ECM, extracellular matrix; MMP, matrix metalloproteinase activity, we added EDTA at a final concen- tration of 5 mM to 

Matrix Metalloproteinase-9 Promotes Chronic - Cell Press

by MH ndez del Cerro 2010 Cited by 158 enzyme activities, MMP-9 has been defined as an exquisite target in c The Ig status and the CD38 and ZAP70 expression in B-CLL cells has 

Membrane Type-1 Matrix Metalloproteinase - MDPI

by LA Marquez-Curtis 2012 Cited by 6 endopeptidases whose expression and activity are upregulated in most cancers [​1 5]. of MT1-MMP in AML cells and the effect of TNF-α on it.


by MA Viani Western blot analysis of MMP-9 activity in the conditioned media harvested on days 3 differentiation of HL-60 leukemia cells (Gomez DE et al., 1997). TIMP-4​ 

Chloramphenicol Causes Mitochondrial Stress, Decreases

by CH Li 2010 Cited by 70 Biosynthesis, Induces Matrix Metalloproteinase-13 Expression, and. Solid-Tumor Cell inhibited apoptosis, leading to the development of leukemia- like syndrome increases nuclear c-Jun activity, which contribute to MMP-13 expression 

Chemical Tools for Selective Activity Profiling of

by N Amara 2018 Cited by 6 evidence of elevated MMP activity at the interface of a tumor expression levels of MMP-14 by tumor cells and cells within the tumor stroma 

Download PDF - Journal of Cancer Metastasis and Treatment

14 May 2021 MMP-2/-9 and VEGF-A expression and survival of primary AML cells. 40. 41. Methods: In peculiar, the proteolytic activities of MMP-2 and. 78.

Review Matrix metalloproteinases in bone marrow - Digitum

by XF Yu 2006 Cited by 75 expression/activity regulation. Preclinical studies on the role of synthetic MMP inhibitors in leukemia treatment. Because MMPs play a pivotal role in cancer.

Regulation of matrix metalloproteinase expression by dynamic

by J Deschner 2006 Cited by 68 expression of a variety of matrix metalloproteinases (MMPs). data provide evidence that biomechanical signals can downregulate the catabolic activity of fibrocartilage cells in an inflam- scribed with 200U of Moloney murine leukemia virus.

Matrix metalloproteinase9 as the protein target in anti-breast

by CF Adhipandito 2019 Cited by 12 The enzymatic activity of MMPs is due to their cata- lytic site that more MMP9 is expressed at grades 2 and 3 than sion and migration of CLL cells [52].

Effect of Proinflammatory Cytokines, Tumor Necrosis Factor-α

by A Leone 2007 Cited by 23 expression and regulation of matrix metalloproteinase-. 9 in a model support that MAP kinase activity elevates MMP activity which may in turn receptor type 1. Leukemia. 1998;12(7):1136-1143. 22. Pagenstecher A, Stalder AK, Kincaid CL​,.

Pathogenesis of Falciparum Malaria Matrix

by M Prato 2005 Cited by 91 We also show that a specific inhibitor of MMP-9/MMP-13 activity. (Merck's inhibitor I from Invitrogen; TRIzol, Moloney murine leukemia virus reverse tran- scriptase Enhancement of MMP-9 activity and protein/mRNA expression in adherent 

Matrix metalloproteinases 2 and 9 (gelatinases A and B

by JG Edwards 2003 Cited by 99 The expression and activities of MMPs have not been characterised in malignant Total and pro-MMP-2 also contributed to the Cancer and Leukemia Group.

Protein Expression of the Matrix Metalloproteinase - Longdom

protein expression of MMP -1, -2, -3, -9 and -14 was qualitatively evaluated in 17 EFT and MB samples of children transcription, 2) proenzyme activation, and 3) inhibition by the action of tissue inhibitor Ph+ acute lymphoblastic leukemia.

Matrix Metalloproteinase - Sigma-Aldrich

recombinant, expressed in transfected cells. Catalog Number Human Matrix Metalloproteinase-9 (MMP-9) is a matrix MMP-2 and MMP-9 also possess collagenolytic activity. MMP-2 myeloid leukemia cells, and U937 monoblastoid cells).


by F Hajighasemi Cited by 2 including leukemia and has an essential role in tumor invasion, metastasis and angiogenesis. In this study, patterns of MMP-9 activity in a 

Effect of macrophage differentiation and exposure to mildly

tein) and increased the activity of nuclear factor- B and ac- tivator protein-1 in cells, an increase in the expression of MMP-1 and -14 has been reported 

Matrix metalloproteinases in the adult brain - EMBO Press

by L Kaczmarek 2002 Cited by 192 proteins that can bind MMPs and block their activities regard to MMP expression are the cerebellum and the blastic differentiation of K562 leukemia cells.

MMP-9 affects gene expression in chronic lymphocytic

by N Aguilera-Montilla 2019 Cited by 8 Keywords: Chronic lymphocytic leukemia; MMP-9; gene regulation; CD99;. 50 MMP-9 activities and local high MMP-9 expression contribute to CLL cell. 80.

CD38 signals upregulate expression and functions of - Nature

by T Vaisitti 2013 Cited by 16 metalloproteinase-9 in chronic lymphocytic leukemia cells (a, b) Expression and activity of MMP-9 was measured by gelatin zymography in a cohort of CLL 

Matrix metalloproteinases - Oxford Academic Journals

by N Merchant 2017 Cited by 105 Several investigations have shown that MMPs manipulate the activity of non-​ECM molecules, including cytokines Aberration in the expression of MMP is associated with a vari- Pediatr. Blood Cancer, 51, 589 592. 37.

Notch1 signaling pathway participates in cancer invasion by

by B Yu 2012 Cited by 24 human cancers, including T-cell acute lymphoblastic leukemia, lung, colorectal Figure 3. The protein expression and activity of MMP-2 and MMP-9 in UM1,.

Interleukin-6 increases matrix metalloproteinase - Oncotarget

12 Aug 2016 attention has focused on the enzymatic activities of MMPs; however, the regulatory that p53 expression decreases MMP-14 mRNA and protein levels and attenuates related cousin leukemia inhibitory factor (LIF) have.

implications in childhood leukemia

4 Dec 2019 advances targeting MMPs in childhood leukemia. Several studies increased MMP-2 expression and gelatinolytic activity, and sub- sequent 

Matrix metalloproteinase synthesis and expression in isolated

cated as sites for synthesis and expression of MMPs within the ECM, whether the LV activity and relative content of the 72-kDa gelatinase MMP-2. Although robust teinase 9 from U937 monocytic leukemia and HT1080 fibrosar- coma cells.

Melatonin inhibits IL1b-induced MMP9 expression and activity

by R Otton 2004 Cited by 128 in regulating MMP genes expression, thus the function of. NF-kB in HUVECs' activity of MMPs can be regulated at several levels: gene expression lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via 

Fibronectin Increases Matrix Metalloproteinase 9 Expression

by SW Han 2006 Cited by 140 The potent proteolytic activities of MMPs are mainly regulated by the con- comitant MMP-9 gene expression in human HL-60 myeloid leukemia cells and blood.

Matrix Metalloproteinase - Korea Science

by VT Nguyen 2011 Gelatinase (MMP-2 and MMP-9) activity and plays an important role in expression of MMP-2 activity in human ovarian carci- e.g. acute leukemia. Crit. Rev.

The role of matrix metalloproteinase-2 in glioma invasion - UR

by ND Sauers 2001 changes in MMP-2 expression level on the invasiveness of gliomas. Gliomas binding and inhibiting the activity of all members of the MMP family (Gomez et al.,​.

Matrix Metalloproteinases in Renal Development and - JASN

by O LENZ 2000 Cited by 337 MMP expression or activity will directly translate into altered. ECM turnover, which from U937 monocytic leukaemia and HT1080 fibrosarcoma cells. Biochem J 

Nucleophosmin Mutants Promote Adhesion, Migration and

by J Xian 2016 Cited by 31 MMP-2 expression associated with leukemic skin infiltration. Taken together, our results ble for the infiltration activity of AML with mutated.

Cell-surface MMP-9 regulates the invasive capacity of

by J Paupert 2008 Cited by 60 associated substrates, the concentration of MMP-9 activity in leading edge of Thus, expression of cell surface MMP-9, within leukaemia.

Bone Morphogenetic Protein-2 Suppresses Invasiveness of

by T KUMAGAI 2006 Cited by 14 down-regulated the activity of MMP-9, but not of MMP-2 or. uPA. BMP-2 also factor and induces the expression of genes that mediate the biological activities of metalloproteinase-9 gene: potential role in mediating adult T-cell leukemia.

Expression of Matrix Metalloproteinases, Tissue - JSTOR

by Y Morimoto 1997 Cited by 39 Chrysotile or RCF stimulated the expression of MMP-1 mRNA in the lung. The However, the activities of MMPs are Moloney murine leukemia virus-derived.

Angular dependence and thermal stability of coercivity of Nd

by J Li 2020 Cited by 8 CD147 expression in CLL-B cells and. proMMP2 activity increased after Fb interaction, which reinforce the idea of a role of. CD147 and consequently MMPs in 

University of Groningen The possible role of matrix - CORE

by G Klein Cited by 426 a possible role for interfering with MMP-activity in acute leukemia will be discussed. 2. Matrix metalloproteinases. Matrix metalloproteinases are 

Involvement of reactive oxygen species in aclarubicin-induced

by D Richard 2002 Cited by 25 found in leukemia cells or cell lines (22). MMPs expression, secretion and activity are highly regulated, particularly by a family of highly specific 

Marrow matrix metalloproteinases (MMPs) - Wiley Online Library

by LI Lin 2002 Cited by 102 inhibitors of MMP in acute leukaemia: potential role of MMP-9 The catalytic activities of MMPs expression was observed in some high-grade non-​Hodgkin's.

mary chronic lymphocytic leukemia cells in vi - Haematologica

by A Schulz 2011 Cited by 86 expression of these two T-cell chemokines in CLL/nurse-like cell co-cultures.3 In known to have chemotactic activity for leukocytes.4 Further novel genes in matrix, MMP can also process cell surface receptors and bioac- tive factors, such​ 

Pericellular proteolysis in cancer - Genes & Development

by L Sevenich 2014 Cited by 153 the proteolytic activity of cancer cells could be responsible for the degradation of the oncogene can lead to increased expression of MMPs and. uPA in ErbB2-​driven contributed to CNS involvement in acute leukemia (Feng et al. 2011).

Upregulation of matrix metalloproteinase-9 in the

by A Kirchner 2000 Cited by 41 MMP-9 activity in 26 of 31 (84%) CSF sam- ples from NB4: cell culture media from NB4 leukaemia cells were activated MMPs expressed in immune cells.

Increased Matrix Metalloproteinase Activity and Selective

by CV Thomas 1998 Cited by 627 regulate MMP activity. However, the types of MMPs and TIMPs expressed within the normal and DCM LV myocardium and the relation to MMP activity remain unexplored. leukemia and HT1080 fibrosarcoma cells. Biochem J. 1992;285:.

Leukemia/Lymphoma - J-Stage

by K Karube 2004 The neoplastic cells of adult T-cell leukemia/lymphoma (ATLL) invade various body organs The expression of matrix metalloproteinase 2 (MMP-2) mRNA was significantly ship with proliferative activity and p53 expression.

View PDF - BMC Cancer - BioMed Central

15 Jan 2015 Background: Adult T-cell Leukemia (ATL) is a disease with no known cure. levels as well as on MMP-9 activity and expression both at the 

Matrix Metalloproteinases: A Review - SAGE Journals

by H Birkedal-Hansen 1993 Cited by 3723 The regulation of MMP activity at the transcriptional Stimulation and Repression of MMP Expression karyoblastic Differentiation of K562 Leukemia Cells.