Normal Tissue And Solid Tumor Effects Of Hyperthermia In Animal Models And Clinical Trials

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Normal Tissue and Solid Tumor Effects of Hyperthermia in

[CANCER RESEARCH 39, 2245-2251 , June 1979] 0008-5472!79!0039-0000$02.0O Normal Tissue and Solid Tumor Effects of Hyperthermia in Animal Models and Clinical Trials'

Hyperthermia and Thermosensitive Liposomes for Improved

outcome of these treatments.Presently,hyperthermia Fig. 1 Beneficial effects of hyperthermia on liposome extravasation and drug delivery to solid tumors. A. liposomes by virtue of their prolonged circulation capacity and small size may extravasate from tumor vasculature, which is more permeable than normal vasculature. B. Hyperthermia is known

Tncologist he

joratively. Examples include understanding the effects of molecular interventions on radiobiology assays of cell sur-vival, DNA repair, cell cycle perturbation, and drug radia-tion interaction. Although animal models remain to be optimized for tu-mor-related studies, normal tissue radiation and combined Low dose High dose Hodgkin s disease

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animal models and 2154 hours in humans- 12. These circulation properties result in an increased accumulation of liposomal drug in the tumor area. This process of liposome accumulation is called passive targeting and it is due to the enhanced permeability and retention (EPR) of tumor tissue 13. For efficient localization at the tumor site, the


using animal models [35-41], as well as in clinical trials, the first of which have been described in publications by Jordan and coworkers [27, 28, 42-44]. Magnetic particles used in MFH are mostly the magnetic iron oxides Fe. 3. O. 4 (magnetite) and γ-Fe. 2. O. 3 (maghemite), as they are recognized for their biocompatibility and safety

Henry Ford Hospital Medical Journal

the theory of normal tissue physiologic adaptation to hyperthermia, and is consistent with augmented blood flow.(24) When external radio frequency hyperthermia is applied to canine normal viscera, no selective heating of any normal organ occurs. C. Animal Tumor Investigations

RESEARCH Open Access Sodium arsenite and hyperthermia

arsenite and hyperthermia modulate mechanisms of cis-platin resistance in vivo. We developed murine models of HIPEC treatment and metastatic human EOC to investigate if NaAsO 2 and hyperthermia alter the expression of DNA repair proteins and tumor platinum levels. We show that NaAsO 2 and hyperthermia either as single agents or in combination


tissue and solid tumor effects of hyperthermia in animal models and clinical trials. Cancer Research 39: 2245-2251. June 1979. 6. Suit H. D., Shwayder: Hyperthermia: Potential as an antitumor agent. Cancer 34: 122-129, 1974. sensitivity of cancer cells: Biochemical and Clinical studies. Cancer 20: 1351-1381, 1967. 8. Kase K., Hahn G. M

References -

Ferry DR, Traunecker H and Kerr DJ. Clinical trials of P-glycoprotein reversal in solid tumours. Eur. J. Cancer 32: 1070-1081 (1996). Fischer V, Rodriguez-Gascon A, Heitz F, Tynes R, Hauck C, Cohen D and Vickers AE. The multidrug resistance modulator valspodar (PSC 833) is metabolized by human cytochrome P450 3A. Implications

In the Name of God Qazvin University of Medical Science

)The hypoxic conditions that are found in necrotic areas of solid tumors( The major problem with using bacteria as anti-cancer agents is their toxicity at the dose required for therapeutic efficacy Restrict to preclinical animal models by: Mohammad Sekhavati / 6 Dr. M. Aslanimehr

Prostate Cancer Imaging and Therapy: Potential Role of

lymph node tissue, there is often both tumor replacement of nodal tissue and abnormalmacrophage activity, resulting in materialthatis not taken up or is taken up inconsistently. The iron nanoparticles thus act as a negative contrast agent, with normal lymph nodes showing a low signal. A recent study involving ferumoxtran-10

Biology of local heat therapy for cancer

rapidly from the tumor tissue than from adjacent normal tissues. As a result, the tumor tissue reaches higher steady-state temperature; thus multiplying the selective effects of heat on individual tumor cells. This double-edged sword, in principle, provides a significant therapeutic lever for the selective destruction of tumor tissue.

Gold nanoshell-localized photothermal ablation of prostate

localized hyperthermia has been shown to be highly effective for photothermal cancer therapy, resulting in cell death and tumor remission in a multitude of preclinical animal models. Here we report the initial results of a clinical trial in which laser-excited gold-silica nanoshells (GSNs) were used in combination with

ABSTRACT PRUITT, AMY FORISTER. Heat Induced Reporter and

ABSTRACT PRUITT, AMY FORISTER. Heat Induced Reporter and Therapeutic Gene Expression in Cancer Gene Therapy. (Under the direction of Marlene Hauck.) Gene therapy for cancer is an

Evaluation of microwave hyperthermia applicators

normal tissue during hyperthermia treatment [Song, 19831. Although there are many encouraging clinical results, hyperthermia remains significant enhancement in tumor response due to

Thermosensitive liposomes for the delivery of cancer therapeutics

mulation at tumor sites. Increased accumulation is due to the relative leakiness of tumor vascu-lature in comparison with normal vasculature. This allows extravasation of long-circulating small (100 nm) liposomes in animal tumor models [10,11], as well as in cancer patients [12,13]. Clinical studies, mainly performed with the

Sorafenib and locoregional deep electro‑hyperthermia in

and taxanes, show no dependency to hyperthermia (9). In certain animal models, several drugs (including KB‑R8498, flavone acetic acid, vinblastine and combretastatin) have been observed to induce a temporary reduction in tumor blood, but only in combination with hyperthermia significant tumor responses (10).

Vascular Targeting Agents as Cancer Therapeutics

Fig. 2 The typical tumor vessel congestion and massive tumor necrosis seen after administration of VTAs to animal models. H&E sections of a rat fibroblast tumor, FE8, 1 h after injection of (A) saline or (B) tissue factor targeted to the angiogenesis marker fibronectin ED-B domain [scFv(L19)tTF].

Hyperthermia approaches for enhanced delivery of

vascular permeability in the heated tumor tissue (Song, 1984). Combination Effects of Hyperthermia animal models, and clinical trials (Falk, 2001). However, clinical adoption of

Novel Approach for Magnetic Nanoparticle-based Hyperthermia

magnetic hyperthermia in clinical trials [12] and animal models [13]. The challenge is how to deliver a sufficient amount of the magnetic particles to generate enough heat in the target using Alternating Current (AC) magnetic field conditions that are clinically acceptable and could be safely used in human patients. For example, a study in

Safety and efficacy of targeted hyperthermia treatment

tissues. Parenteral administration of gold nanorods (NRs) as a photosensitizer amplifies the effects of hyperthermia treatment while sparing normal tissues. This therapy is well tolerated and has demonstrated anti-tumor effects in mouse models. The purpose of this phase 1 study was to establish the safety and observe the anti-tumor impact of

Innovation and Development of Study Field Nanomaterials at

addition to tumor cells, leading to adverse side effects such as nausea, neuropathy, hair-loss, fatigue, and compromised immune function. Nanoparticles can be used as drug carriers for chemotherapeutics to deliver medication directly to the tumor while sparing healthy tissue. Nanocarriers have several advantages over conventional chemotherapy.

REVIEW Open Access - Springer

but still was not devoid of animal deaths [13]. C. novyi has also been investigated in conjunction with radiotherapy, radioimmunotherapy, and further chemotherapy in experimental tumor models [14,15]. The results have demonstrated the potential of combined multi-modality approaches as developmental future cancer therapies. C.

Oncolytic virotherapy in veterinary medicine: current status

addressed to improve efficacy, safety and clinical applic-ability. An overview of some of the problems and solu-tions is described here. 3.1 Selective targeting of oncolytic virus to tumor tissue A major caveat for the widespread clinical use of vir-otherapy in canine cancer is to ensure that viruses do not harm normal cells.


was isolated and tested in animal tumor models (15). Tumor lysis was observed in spore-treated animals. These encouraging results eventually led to clinical trials in which the C. sporogenes spores were used to treat a limited number of patients with different cancer types (16). Although initially promising, these early studies

Characterization of X-linked Hypohidrotic Ectodermal

Clinical characteristic n % n % Heat intolerance 12 100 0 0 Exercise limited by heat intolerance 10 83 0 0 Decreased sweating 12 100 1 8 Unexplained fevers 2 17 0 0 Dry skin/eczema 12 100 n/aa Thinning hair and/or eyebrows 8 67 n/a Fingernails/toenails appear normal 9 75 n/a Chronic childhood nasal drainage/blockage 11 92 n/a

Theoretical Feasibility of Vasodilator-enhanced Local Tumor

ratio of tumor to normal tissue perfusion. This concept is presented by means of the electrical analogy in Fig. 1. In the figure the variable resistor (R 1) denotes normally reactive arterioles and the fixed resistor (R 2) denotes tumor vessels. The series resistance (R s) denotes the normal arterioles which branch to feed both tumor and normal

Journal of Biomedical Science

photodynamic therapy, HAMLET (human alpha-lactalbumin made lethal to tumor cells), gene therapy, telomerase therapy, hyperthermia therapy, dichloroacetate (DCA), non-invasive RF cancer treatment, complementary and alternative therapy, diet therapy, insulin potentiating therapy and bacterial treatment [1].


hyperthermia. Hyperthermia is the application of heat to destroy solid tumours, which has been used as an adjuvant cancer treatment for some time but is not currently utilized as an independent treatment. Hyperthermia induces cell death through mechanisms such as rupture of cellular membranes and protein denaturation.

Nanoparticles for Thermal Cancer Therapy

proaches have demonstrated high efficacy in animal models, and two are already in human clinical trials. DOI: 10.1115/1.3156800 1 Introduction Over the past 50 years, despite tremendous advances in our knowledge of the genetic, molecular, and cellular underpinnings of cancer, there has been no change in the age-adjusted mortality from cancer 1

Biochemical and Metabolomic Changes after Electromagnetic

May 17, 2021 duces necrosis, carbonization or coagulation of the tissue [9]. At the tissue level, HT causes changes to the pH levels, to the perfusion and oxygenation of the tumor microenvironment, and therefore to the tumor itself [10]. Our research group has solid experience in the field of hyperthermia. For more than

Ultrasound drug targeting to tumors with thermosensitive

animal models (unlike clinical MRgFUS instruments), and permits us to screen formulation and cancer models more efficiently. The induction of hyperthermia in mouse footpad tumors was rapid, with elevation of tissue temperature to 42.6 +/- 0.6oC (SD) within 30 seconds. When the transducer was energized,