The Fatty Acid Composition Of Human Gliomas Differs From That Found In Nonmalignant Brain Tissue

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Comparison of Elemental Anomalies Following Implantation of

by K Planeta 2020 Cited by 1 Different Cell Lines of Glioblastoma Multiforme in the Rat Brain: A. Total Reflection purposes, and one possibility is the implantation of human tumor cells into One of the most common primary brain tumors are gliomas, which usually the lipid components in the tissue, serum, and CSF of the patients.

Heterogeneity of Human Gliomas: Glutathione-S-Transferase

by R TJIONG 2019 Cited by 3 differences in gene and protein expression were detected between the different also assumed that a higher percentage of glioblastomas after Perilesional brain tissue from resections of deep-seated benign Tissue sampling and isolation of nucleic acids. Tissue For blocking, 5% dry non-fat milk (Cell Signaling,.

Raman spectroscopy for medulloblastoma

by B Polis 2018 Cited by 9 normal tissues from the safety margin of the CNS and to find specific Raman biomarkers capable of differentiating between tumorous and 18 years of age, it constitutes 18% of all brain tumors and 30% concerning the (1996) The fatty acid composition of human glioma differs from that found in nonmalignant brain tissue.

Accepted manuscript - Research Explorer - The University of

by A Nicolaou concomitant with the increase in PGE2 content found in many tumors [7-9]. PGE2 is considered Fatty acid composition differs between grade II/III gliomas and GBMs benign, atypical, and anaplastic meningiomas. Prostaglandin E2 levels in human brain tumor tissues and arachidonic acid levels in the.

Assessment of 31P-NMR analysis of phospholipid profiles for

by J Solivera Cited by 26 nolamine plasmalogen; FFA, free fatty acids; GroPCho, glycerophosphocho- brain tissue and different human intracranial tumors, as obtained acid composition of human gliomas differs from that found in nonmalignant brain tissue.

A perspective on the radiopharmaceutical requirements for

General and normal brain tissue toxicity a. of distinct cell populations with differing sensitivity to therapy. Amino acid radiopharmaceuticals designated for may distinguish high-grade glioma, brain metastases and benign lesions in composition of the GB microenvironment, facilitating tumor aggressiveness upon​ 

Tenascin Expression Patterns and Cells of Monocyte - Nature

by A Kulla 2000 Cited by 28 Stromal extracellular matrix (ECM) components are gen IV, and tenascin (TN) in human gliomas, with brain macrophages that appear in different patho- 3-​amino-9-ethylcarbazole (DAKO) as the chromo- specimens also contained peritumoral brain tissue. peripheral areas of both malignant and benign gli- omas.

Malignant astrocytic glioma: genetics, biology - Genes Dev

by FB Furnari 2007 Cited by 2485 approaches, destruction of normal brain tissue, and cer- tain death. logically benign and can be cured if they can be thologist in distinction of different glioma classes. Since mutant H-ras is seldom seen in human tumors, it Suberoylanilide hydroxamic acid by a C-terminal 14-amino-acid sequence with significant.

13. Nucleic Acid Contents and their Metabolism in - J-Stage

by K KITAMURA 1963 left-right difference of insensible water loss of body showed marked tendency in the case of cerebral tumors, in Human Brain Tumors. Katsutoshi 2) Lipid phosphorus was found much higher in the normal brain tissue than in the tumors. On a protein base, high concentration was estimated in the benign gliomas, such.

Download PDF - SAGE Journals

by MA Kiebish 2009 Cited by 53 differences were found between normal tissue and Abnormalities in mitochondrial lipid composition could produce If lipid or fatty acid metabolism is altered in brain Campanella R (1992) Membrane lipids modifications in human gliomas of properties of malignant and nonmalignant lymphoblasts cultured in vitro.

Absolute concentrations of metabolites in human brain tumors

by Y Kinoshita 1997 Cited by 240 reveal MR spectral changes in accordance with the density of glioma cells. meningioma; instead, there was an increased alanine content. lactate, inositol, mannitol, and amino acids such as tissue. The concentration of each metabolite in normal brain tissues central and marginal portions of the tumor at five different.


by L Mörén 2015 for biomarkers or biomarker patterns in two different types of brain tumors, HSP90, was found elevated in relation to treatment in tumors, following ELISA Keywords: Glioblastoma, glioma, meningioma, metabolomics, proteomics, mass- [54] and that tumor tissue lipid levels are higher compared to normal tissue in.

Cation selectivity and inhibition of malignant glioma Na+

6 Nov 2017 inhibits cation currents mediated by acid-sensing ion channels amiloride-​sensitive sodium current cannot be detected in astrocytes obtained from normal human brain tissue or from glioma cells derived from low-grade or benign tumors. culturing human malignant glioma tissue samples were reviewed 

Raman imaging and statistical methods for analysis - bioRxiv

by M Kopec 2021 imaging can be used to analyze various types of human brain tissue. Malignant glioma is the most common type of primary brain tumor. benign and slow-​growing. In this paper we present Raman spectroscopy as a tool for This study expands our previous research by adding lipid content as an 

Role of the regulation of cell lipid composition and membrane

by M Laura Martin Cited by 2 However, only traces of free fatty acids are present in free form in tissues and cells. The of human gliomas differs from that found in nonmalignant brain tissue.

55-5-528.pdf - Oxford Academic Journals

by W Paulus 1996 Cited by 117 protein levels in normal human brain and in gliomas, medulloblastomas, schwannomas, mRNA was detected in all tissues except for medulloblastomas. splicing, at least four different versican isoforms are gen-. The composition of the cerebral extracellular matrix erated, diftering in their GAG attachment domains: VO.

Docosahexaenoic Acid: A Potential Modulator of Brain Tumors

20 Oct 2013 The lipid composition of the cellular membrane varies among cells of contained 70-80% less DHA than normal brain tissues [25]. This acid composition of human gliomas differs from that found in nonmalignant brain 

Label-Free Delineation of Brain Tumors by Coherent Anti

by O Uckermann 2014 Cited by 75 Methods: Different human tumors (glioblastoma, brain metastases of addressed and tissue regions characterized by high lipid content composition of human gliomas differs from that found in nonmalignant brain tissue.

Download PDF - Genome Medicine - BioMed Central

by C Denkert Cited by 108 in human breast cancer tissues can be maximized by combining different [18​] for polar membrane lipids, how is the main fatty acid produced in cancer cells than in non-malignant cells is typically found in tumor cells but not in normal cells, cancer, human brain tissue, liposarcoma, malignant.

To see the effect of phospholipid derived from soybean

by SR Jaiswal 2010 The fatty acid composition of human gliomas differs from that found in non-​malignant brain tissues. The content of omega-6. PUFA linoleic acid was found to be 

Human glioma tumors detection by a portable visible

by Y Zhou Cited by 1 analysis of changes in tumor chemical compositions in molecular level. of human brain tissues that we have found from our experiments since 2011 [4, 5,7,​14]. probe which can be used for analysis of glioma tumors in different grades and fatty acids revealed a rapid decrease in the high-grade of glioma brain tissues.

Interaction of brain fatty acid-binding protein with the

by ME Elsherbiny 2013 Cited by 37 Names of different fatty acid binding proteins (FABPs) and the tissues from which composition of human gliomas differs from that found in nonmalignant brain.

Glioma Stem Cell Specific Superenhancer Promotes

by RC Gimple 2019 Cited by 36 in gliomas with enrichment for free fatty acids and polyun- epigenetic landscape of three human patient derived GSCs 10 glioblastoma tissue samples and 15 normal brain tissue samples based on H3K27ac other tumor cellular components, including astrocytes, A, Volcano plot showing differ-.

a novel alternate pathway for long chain polyunsaturated

by W Park 2010 Long chain polyunsaturated fatty acids (LCPUFA), especially arachidonic acid. (​ARA FADS1, FADS2, and FADS3 are localized within a 100 kb region on human associated with phospholipid fatty acid composition (Benatti et al., 2004​). Ratio tissues, the most prevalent regulatory tissues for this event are in the brain.


by R MARSZAŁEK Cited by 4 Brain tissue samples were collected from patients with intracranial tumors during surgery, frozen reduced. Keywords: 1H MAS NMR, solid state NMR, fatty acids composition, brain tumors, glioblastoma, meningioma, tion of human gliomas differs from that found in patients and from 3 nonmalignant patients were ana-.

Inhibition of Cystine Uptake Disrupts the Growth of Primary

by WJ Chung 2005 Cited by 312 1a). Importantly, prominent expression of xCT was also found in biopsies from glioma patients and in biopsies obtained from nonmalignant brain tissue (Fig. 1b)​.

methionine after tumor resection in rat glioma m - Journal of

by S Geisler 2019 Cited by 4 of residual tumor after surgery by amino acid PET seems to be more tumor resection in two different rat glioma models (F98 and GS-9L) days) underwent resection of normal brain tissue without previous is typical for benign lesions. however, similar phenomena appear to present in humans and 

NIH Public Access - Questions and Answers ​in MRI

by EJ Delikatny 2011 Cited by 143 models of cancer as well as human brain tumors will also be discussed. mobile lipids; lipid droplets; neutral lipids; triglycerides and cholesterol esters; apoptosis find its way into a new tissue type, phenotypically readapt to the new components observed in the cell, with additional contributions from the often cellular- or.

Optical biopsy identification and grading of gliomas using

by Y Zhou 2019 Cited by 17 high grade (grades III and IV) gliomas are found to be 96.3%, 53.7%, and 84.1% for the A set of criteria for differentiating normal human brain tissues from changes of the chemical composition of different lesions in fatty acids) and proteins (full amino acids contribution) in cells considered to be at the benign level.

Analysis of human brain tissue, brain tumors and tumor cells

9 Feb 2021 differences were found in IR spectra of low and high grade glioma tissue sections pointing to a significant for the lipid to protein ratio was introduced involving the CH2 symmetric cantly increase the information content of IR spectroscopy. strating a histological continuum from almost benign tumors.

Immunocytochemical Study of Transforming Growth - NCBI

by V Samuels 1989 Cited by 131 brain. TGF-beta was detected in both benignand malignant tumors, but was not Benign gliomas con- Twenty human glioma biopsies obtained from archival tate immunologic staining in tissue sections.9 10 To obtain Statistical differences between groups anoma cells: Amino acid sequence homology with epider-.

Download PDF - Spandidos Publications

by KD Geiger 2011 Cited by 28 (gpI)-anchored cell surface protein, in gliomas of different. WHo grades absent in normal brain tissue, but was detected in WHo grade. III-IV gliomas. pasching, Austria), 4x non-essential amino acids (gibco-Brl, eggenstein PSCA expression in human glioblastoma samples. We exam- to benign brain tumors. pscA-Ir 

Long-Term Effect of Docosahexaenoic Acid Feeding - MDPI

by ME Elsherbiny 2015 Cited by 24 on Lipid Composition and Brain Fatty Acid-Binding 1. Introduction. Human brain development starts at the fifth postmenstrual week and continues after birth with gliomas differs from that found in nonmalignant brain tissue.

The highly unnatural fatty acid profile of cells in culture

by P Else 2020 Cited by 8 Cells in culture are often used as surrogates for researching natural tissues, made from human serum (see Table 1 for the relative fatty acid composition of composition of human gliomas differs from that found in nonmalignant brain tissue,.

The fatty acid composition of human gliomas differs from that

by DD Martin 1996 Cited by 82 The Fatty Acid Composition of Human Gliomas. Differs from That Found in Nonmalignant Brain Tissue. Douglas D. Martin a'l, Michael E.C. Robbins a'*, Arthur A.


by CC Sung 1995 Pearl, D.K Glycolipid Composition of Human Gliomas. The 4th 2.1 Flow chart illustrating the processing of tumor tissue, gangliogide tumors with different patterns of expression of lb gangliosides lipid extracts of kidney and brain detected using the reactions with in benign and malignant gastrointestinal mucosa.

Lipids in Health and Disease - CORE

by J Nasrollahzadeh 2008 Cited by 27 docosahexaenoic acid rich oils on rat brain tumor fatty acids composition and brain tis- sue and have found that concentration of n-3 fatty acids, tumor tissues but DHA levels only increased relative to fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue. Lipids.

Effect of Hydrophilic Components of the - AJR

by N Sadeghi 2003 Cited by 80 expression of hyaluronan or hyaluronic acid as one of the main hydrophilic components of Nineteen patients with primary glial brain tumors A positive correlation was found between mean ADC lular matrix in gliomas likely contributes to differences in the ADC values fers to the percentage of tissue area specifically.

Glioblastoma-infiltrated innate immune cells - JCI Insight

25 Feb 2016 Contrary to current dogma, GAMs exhibited distinct immunological functions, with the by MYC and E2F, protein secretion, oxidative phosphorylation, and fatty acid from resected glioblastoma (GBM) tissue or nonmalignant brain tissue Monocyte subpopulations in human gliomas: expression of Fc and 

tumour brain tissue - Wiley Online Library

by G Petersen 2005 Cited by 81 meningiomas compared to human non-tumour brain tissue. Gitte Petersen,* Birthe 1992), has been found to exert not only anti-proliferative but also pro-​apoptotic of human gliomas compared with non-malignant brain tissue has also been (1996) The fatty acid composition of human gliomas differs from that found in 

possible role in gliomas and meningiomas - Journal of Clinical

by N Nathoo 2004 Cited by 91 These data suggested that the fatty acid composition of human brain tumours is different from that found in non-tumorous brain incorporated into brain tumour tissue than normal brain and benign brain tumours. Simmet et 

Enhanced anticancer properties of lomustine in conjunction with

human brain microvascular endothelial cell; HCCMEC = human cerebral cortex Gas chromatography analysis of the fatty acid profile in The fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue.

Growth Factors in Glioma Angiogenesis - Dunn Laboratory

by IF Dunn 2000 Cited by 291 amino acids) with a molecular mass of 18 kDa [43,46]. (Table 1). compared to nonmalignant control brain tissue [67]. lular matrix (ECM) components including fibronectin The details of TGF-β signaling differ. growth factors have been detected in gliomas, func- expressed in human gliomas also showed that FGF-2.

Macrophage Ontogeny Underlies Differences in - Cell Press

by RL Bowman 2016 Cited by 253 and metastatic disease in mouse and human. macrophages and uncovering tissue-specific gene expression contralateral, non-malignant brain contained only GFP. À. MG, proteases, lipid metabolism mediators, and clotting factors were increased TAM BMDM content in the GL261 glioma model, a.

Label-Free Macroscopic Fluorescence Lifetime - Frontiers

by M Lukina 2021 Cited by 1 biosynthesis of fatty acids and nucleotides and in detoxifying processes. (P)H fluorescence, including emission intensity, spectrum profile and the lifetime glioma and healthy brain tissue from the animal models and humans present different signatures in terms of the Nonmalignant Oral Mucosa Cells.

20 Multiphoton microscopy and fluorescence - De Gruyter

by SR Kantelhardt 2018 Cited by 2 Unfortunately it can be difficult to discriminate tumor and adjacent brain tissue in- We could show that the technology is able to clearly discriminate different cells and benign glioma, the pilocytic astrocytoma is grade I [3]. heme biosynthesis: 5-amino laevolinic acid (5-ALA) [10, 28, 29]. ability of cellular components.

Original Article A high expression of MTERF3 correlates with

15 May 2019 brain glioma tissues are significantly higher than they are in the get gene has been found in gliomas, and the consists of 417 amino acid residues and five dimethylbenzene and rehydrated in a different percentage of tumor cells. human noncancerous brain tissues, high-grade and low-grade 

Essential fatty acids enhance free radical generation and lipid

by U Das 2011 Cited by 53 high content of vitamin E and enhanced levels of PGs may be responsible for the low rate of lipid peroxidation seen in tumor cells [48,49]. Free radicals have 

Proton MR Spectroscopy of Pediatric Cerebellar Tumors

by Z Wang 1995 Cited by 137 copy studies of human brain tumors have been whether MR spectroscopy is helpful in differ- brain tissue surrounding the tumor and any cysts inside the tumor. Major components found in the proton MR spectra were Sometimes lipid signals also were present in the of mixed glioma ependymo-astrocytoma, ana-.

Human brain cancer studied by resonance Raman spectroscopy

by Y Zhou 2012 Cited by 130 The peak around 1732 cm−1 attributed to fatty acids (lipids) are principal components are used. Keywords: resonance Raman spectroscopy; brain tissues; statistical analysis differences of RR spectra were found between cancer and tumor tissue diagnosed as grade IV (top), benign human acous-.