A Newborn Mouse Model For The Study Of Intestinal Pathogenesis Of Shigellosis

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Sumoylation controls host anti-bacterial response to the gut

previously reported newborn mouse model of intragastric (i.g.) infection [15]. The impact of sumoylation on infection was tested using Ubc9+/ mice compared to Ubc9+/+ mice. We inoculated i.g. 4-day-old newborn mice for 3 h with the invasive isolate M90T or used physiological water as a control. By performing immunofluo-

Specific Etiologies of Chronic Diarrhea in Infancy

contributing factors to the pathogenesis of viral enteritis (37). During a 12-week study period, Yolken et al. (38) recently demonstrated gastroenteritis caused by enteric-type adenovirus in 14 of 27 cases of diarrhea. Adenovirus was found in the stool of only one of 72 children^vithout diarrhea. There is as yet no specific treatment for viral

A Piglet Model of Acute Gastroenteritis Induced by Shigella

scribed, including a guinea pig model of infection via the rectal route [13] and a mouse xenograft model using human intestinal cells [14]. In the present study, we show that newborn gnotobiotic (GB) piglets orally challenged with SD? develop many of the clinical symptoms and gastrointestinal manifestations that mimic hu man shigellosis.

The Caenorhabditis elegans ABL-1 Tyrosine Kinase Is Required

150 million people annually (22). The study of shigellosis in vivo has been hampered by the lack of a suitable model system. Unlike humans, mice do not develop intestinal disease upon ingestion of S. flexneri. While recent developments of mouse models using newborn mice (17) and infection paired with

A newborn mouse model for the study of intestinal

severe intestinal damage. In contrast, 5-day-old mice inoculated with either the invasive or the non-invasive strain were not infected. We have thus established a mouse model that is suitable for the study of the pathogenesis of intestinal Shigella infection. Introduction Bacillary dysentery or shigellosis, an acute colitis caused

Shigella Vaccine Development: The Model Matters

intraperitoneal infection mouse model of Shigella. infection was proposed, leading to the colonic mucosa invasion, although the dissemination route was not clearly stated [42]. A last interesting mouse model described was the SCID mouse-human intestinal Xenograft model, which consists in the engraftment of human colonic tissue.