High Risk Of Recurrent Venous Thromboembolism In Men

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at preventing recurrent venous thromboembolism.56 Thirdly, the risk of recurrent thromboembolism increases after vitamin K antagonist treatment is stopped.2-47-9 However, the results of these individual trials, and meta-analysis of summary data of their findings,10-14 have failed to answer many important questions relating to the optimal length

Rivaroxaban: Expanded Role in Cardiovascular Disease

recurrent venous thromboembolism. Early discharge within 24 hours after low-risk PE was studied in the HoT-PE (The Home Treatment of Patients with Low-Risk Pulmonary Embolism with the Oral Factor XaInhibitorRivaroxaban)trial.Earlydischargewithrivarox-aban 15mg twice daily for three weeks followed by 20mg

SECTION 22 CHAPTER 145 - portal.icaavcr.com

venous thromboembolism recurrent thrombosis DVT PE risk factors Abstract!e incidence of recurrent, fatal and nonfatal venous throm-boembolism (VTE) is estimated to exceed 900,000 cases annually. VTE is associated with a number of risk factors. !ese include age, immobilization, travel, history of VTE, malignancy, surgery,

The management and outcome of acute venous thromboembolism: A

high-risk situations to assess how difficult cases were treated and what their outcomes were. This will provide a most useful tool for the practicing physician responsible for the management of VTE patients. (J Vasc Surg 2003;38:916-22.) Venous thromboembolism (VTE) remains an impor-tant cause of morbidity and mortality in western countries.

Venous Thromboembolism and Cancer: Risks and Outcomes

Venous Thromboembolism and Cancer: Risks and Outcomes Agnes Y.Y. Lee, MD, FRCPC, and Mark N. Levine, MD, FRCPC Abstract Cancer and its treatments are well-recognized risk factors for venous thromboembolism (VTE). Evidence suggests that the absolute risk depends on the tumor type, the stage or extent of the cancer, and treatment with


Recurrent episodes of VTE appear to fall into two categories: 1) Recurrences may be due to reactivation and extension of the original thrombosis. This risk is very high when patients first present with acute thrombosis; the risk decreases progressively during the first 3 months of treatment.

Long-term outcomes after deep venous thrombosis of the lower

venous thromboembolism. However, symptomatic deep-vein thrombosis (DVT) of the lower extremities carries a high risk for recurrent venous thromboembolism that persists for many years. This risk is higher among patients with permanent risk factors including inherited

Antiphospholipid antibodies and recurrent thrombosis after a

with recurrent VTE. l APA and D-dimer levels seem to be independently associated with recurrence after a first unprovoked VTE. It is uncertain whether antiphospholipid antibodies (APAs) increase the risk of recurrence after a first unprovoked venous thromboembolism (VTE). We tested for anticardiolipin

Identification of Patients at Low Risk for Recurrent Venous

Identification of Patients at Low Risk for Recurrent Venous Thromboembolism by Measuring Thrombin Generation Gregor Hron, MD Marietta Kollars Bernd R. Binder, MD Sabine Eichinger, MD Paul A. Kyrle, MDA NTICOAGULANT TREATMENT for patients with venous thromboembolism (VTE) consists of low-molecular-weight heparin with therapeutic doses

Men had greater risk of recurrent venous thromboembolism than

which women and which men are at such high risk of recurrent thromboembolism that they are appropriate candidates for extended anticoagulant treatment. Richard H White, MD University of California, Davis Sacramento, California, USA 1 Baglin T, Luddington R, Brown K, et al. Incidence of recurrent venous thromboembolism in relation to clinical

Validating the HERDOO2 rule to guide treatment duration for

unprovoked venous thromboembolism (VTE, proximal classified as at low risk of recurrent VTE and follow-up (8.1%, 5.2% to 11.9%), whereas in 1802 high risk women and men who continued

Long-term, low-dose warfarin among venous thrombosis patients

recurrent venous thromboembolic disease has remained untested. The Prevention of Recurrent Venous Thromboembolism (PREVENT) trial will evaluate the efficacy of prolonged treatment with low-dose warfarin in the secondary prevention of venous thromboembolism (VTE). Patients with a history of documented idiopathic venous thrombosis

Risk of pregnancy-associated recurrent venous thromboembolism

Jul 25, 2004 recurrent venous thromboembolism in women with a history of venous thrombosis. J Thromb Haemost 2005; 3: 949 54. Summary. Background: Limited data exist on the risk of pregnancy-associated venous thromboembolism (VTE) in women with a history of VTE. Objective: To evaluate the risk of recurrent pregnancy-associated thrombosis in women with


To provide guidance on the recommended duration of anticoagulant therapy for venous thromboembolism (VTE). BACKGROUND: Making a decision on the duration of anticoagulant therapy depends on the assessment of an individual s risk of recurrent thrombosis off anticoagulation versus the risk of major bleeding on anticoagulation. While case

Pulmonary embolism: update on management and controversies

Recurrent venous thromboembolism occurs in 30% of people, making the attack rate (including incident and recurrent venous thromboembolism) higher, estimated as up to 30 per 1000 person years.19 The influence of race on venous incidence of thromboembolism is uncertain, but incidence may be higher in white and African-American populations

The epidemiology of venous thromboembolism

risk include recent immobilization, tamoxifen therapy, and Fig. 3 Secular trends in the incidence of venous thromboembolism, deep vein thrombosis alone, and pulmonary embolism [18] Fig. 4 Cumulative incidence of first venous thromboembolism recurrence (continuous line), and the hazard of first recurrence per 1000 person-days (dotted line)[32]

Identifying unprovoked thromboembolism patients at low risk

enous thromboembolism is a common, potentially fatal, yet treatable, condition. The risk of a recurrent venous thromboembolic event after 3 6 months of oral anticoagulant therapy varies. Some groups of patients (e.g., those who had a venous thromboembolism after sur-gery) have a very low annual risk of recurrence (< 1%),1 and

Aspirin for the Prevention of Recurrent Venous Thromboembolism

the Prevention of Recurrent Venous Thromboembolism (the Warfarin and Aspirin [WARFASA]) and the Aspirin to Prevent Recurrent Venous Thromboembolism (ASPIRE).15,16 The tri-als showed that aspirin reduces the risk of recurrent VTE but they were not individually powered to detect moderate treat-ment effects for particular outcomes or subgroups.

Screening for Occult Cancer in Patients with Venous

Jul 27, 2020 provoking factors for VTE and if the VTE is an initial or a recurrent event. Patients with recurrent VTE seem to be at a particular higher risk (OR 4.3; 95% CI, 1.2 to 15.3) compared to patients having a first unprovoked event [3]. Risk factors associated with an increased risk of occult cancer in patients with unprovoked VTE have also been


US, a figure that has not changed in the VTE stands for venous past 10 years. thromboembolism, which includes both DVT and PE. What causes DVT and PE (VTE)? There are many causes of , including genetic risk factors and environmental risk VTE factors. Some risk factors are permanent, and some, like major surgery, are temporary.

A lower risk of recurrent venous thrombosis in women compared

hormonal state to explain the difference in risk of recurrent venous thrombosis between men and women. Because thrombo-philic subjects are at higher risk of venous thrombosis and reveal venous thrombosis at younger age than the normal population,14 hormonal effects on the risk of first and recurrent venous thrombosis may be enhanced in these

Therapeutics EBM verdict Extending anticoagulation

high quality, as rated by the Newcastle-Ottawa scale. The risk of recurrent VTE was 10% in the first year after treat-ment, rising to 36% by year 10; deaths occurred in 3.8% (95% CI 2.0 to 6.1%; I2=59%) of the cases of recurrent VTE (table 1). Men were 1.4 times more likely to have a recurrent VTE than women (95% CI 1.3 to 1.6). The results did

Open Access Protocol Long-term risk of recurrence after

embolism (PE), jointly denoted as venous thromboembolism (VTE), comprise a treat-able yet burdensome condition. 1 2 It is recom-mended that anticoagulant therapy (AT) be continued for at least 3 months in all patients with VTE.3 Thereafter, approximations of the projected long-term risk of recurrent VTE off anticoagulation, risk of major bleeding

Pulmonary Embolism: A Team Approach To Diagnosis and Management

Venous Thromboembolism The Incidence is Increasing MI: # 1 - rate is trending downward Stroke: #2 - rate has plateaued PE/DVT: #3 - rate is increasing in men and women Am J Med 2014;127:829-839 Management of Acute Pulmonary Embolism Risk Stratification


unprovoked VTE patients with sufficiently low or high risk for recurrence to better justify the decision to discontinue or continue OAT (1). The REVERSE I study showed high recurrence risk (13.7%; 95% CI 10.8 - 17.0%) in 332 men with unprovoked VTE but could not find any predictors to identify a low risk subgroup (6).

081700 High Plasma Levels of Factor VIII and the Risk of

high plasma levels of factor viii and the risk of recurrent venous thromboembolism high plasma levels of factor viii and the risk of recurrent venous thromboembolism p aul a. k yrle, m.d., e rich

Risk assessment for recurrent venous thrombosis

high-risk patients, but patients with a positive result are not necessarily at high risk of recurrence of venous thrombosis. In a further meta-analysis,5 the proportion of patients who died of recurrent venous thrombosis decreased from 11 3% during anti-coagulation therapy to 3 6% after anticoagulation, whereas the case

Long term risk of symptomatic recurrent venous

randomised trials, reported an overall risk of recurrent VTE of about 10% per year in the first two years after discontinuation of anticoagulation. That analysis did not assess the risk of recurrent VTE in men and women separately or in patients with isolated pulmonary embolism, and it only followed patients for 24 months.

Refining Risk Prediction for Recurrent Venous Thromboembolism

categorized as low risk, which corresponded to a VTE recur-rence rate of 2.34 per 100 person-years, 7% were at interme-diate risk with a rate of 3.17 per 100 person-years, and the remaining 90% were at high risk with a rate of 7.43 per 100 person-years. Similarly, for women, 7, 73, and 20% could be categorized as low, intermediate, and high


¼ venous thromboembolism INTRODUCTIONA ndrogen use in men aged $40 has increased more than 3-fold from 0.81% in 2001 to 2.91% in2011.1 The broaduseoftestosterone therapy (TT) may have major public health ramifica-tions, given recent reports of thrombotic2-7 and cardiovascular disease (CVD) events8-10 associated with TT. Despite lessons

Duration of Anticoagulation for VTE

VTE risk factor: cancer High risk of recurrence: ~15% per year Active: treated in the past 6 months, persistent, progressive Other factors Chemotherapy Metastases CVC Higher risk cancers High total mortality and VTE mortality High bleeding risk independent of anticoagulation N EnglJ Med 2003; 349( 2): 146 -153

REVIEW Open Access Pharmacokinetic and pharmacodynamic

tinued. VKA therapy is continued for as long as the risk of recurrent venous thromboembolism (VTE) outweighs the risk of bleeding [1,2]. This approach is effective if managed well but does present challenges, both in the acute phase of treatment, when two drugs must be ad-ministered together, and over the course of long-term

Current Status of the Retrieval Rate of Retrievable Vena Cava

reduced the risk of PE in a short period, but the risk of complications increased in the long-term period, such as IVC thrombosis, recurrent VTE, thrombophlebitis, venous stasis disease, and IVCF penetration into adjacent organs [3]. In order to solve these problems, retrievable IVCFs have been developed. Temporary use of retrievable IVCF is a

The risk of recurrence in women with venous thromboembolism

(temporary) risk factor) are at a particularly high risk of recurrence and are regarded as candidates for extended, even life-long, anticoagulation [1]. For so far unknown reasons, men are at a higher risk of recurrence than women [2,3]. In our analysis of 2004, we reported that the risk of recurrence among women

Review Low-molecular-weight heparins in the treatment of

The clinical significance of venous thromboembolism is not only because of the risk of death from pulmonary embolism, but also because of the high risk of recurrent events, the occurrence of subsequent morbidity such as the post-thrombotic syndrome, and the consequent eco-nomic impact caused by the high rate of hospitalization.

Criteria-Based Consultation Prescribing Program CRITERIA FOR

CHA2DS2-VASc score of 1 or greater in men and 2 or greater in women (This score predicts the risk of stroke in patients with atrial fibrillation) ** - AND - Intolerance or contraindication to dabigatran (i.e. unable to swallow whole pills, history of

Venous Thromboembolism in Jamaican Women: Experience in a

14%. Recurrent venous thromboembolism occurred in 12.8% and 15.8 % of women (66) died, diagnosed with PE at post-mortem. Using logistic regression analysis, leading risk factors in fatalities compared to survivors were hypertension and increased age. Obesity and surgery were significantly more likely in survivors.

Deep vein thrombosis and pulmonary embolism

additively or multiplicatively increase the risk of venous thromboembolism by inducing hypercoagulability, stasis, or vascular wall damage or dysfunction (panel).6,17 Strong risk factors for venous thromboembolism include surgery, immobilisation, and cancer. Risk is especially high for patients undergoing major orthopaedic surgery;

Natural history of patients with venous thromboembolism and

9]. Although recurrent bleeding events are the hallmark, some patients with HHT may also develop venous thromboembolism (VTE) [9 11]. HHT patients with acute venous thromboembolism (VTE) are perceived to be at high risk for major bleeding if anticoagulant ther-apy is prescribed, but the evidence on this issue is scarce

Effect of tailoring anticoagulant treatment duration by

as recent surgery) venous thromboembolism (VTE) are at risk of recurrence if anticoagu-lants are stopped after 3 6 months, yet their risk remains heterogeneous. Thus, prolonging anticoagulant treatment should be considered in high-risk patients, whereas stopping is likely preferred in those with a low predicted risk.