Organelle Segregation Into Plasmodium Liver Stage Merozoites

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Centrins,CellCycleRegulationProteinsinHumanMalaria Parasite

vertebrate host, depending on the Plasmodium species, within a period of 2 14 days in liver cells a single sporozoitemayrep-licate into 10,000 40,000 asexual liver-form merozoites. The merozoites invade erythrocytes, and during each intraerythro-cytic replication cycle, a uninucleated merozoite can produce

Molecular Microbiology First published online 17 August 2011

To identify Plasmodium genes with a specific critical func-tion in liver merozoite formation, we systematically searched available data sets for potential liver stage-specific genes of unknown function. We focused on a small Plasmodium-specific gene (PBANKA 010110) expressed during liver-stage development (Tarun et al., 2008).

Chemical Rescue of Malaria Parasites Lacking an Apicoplast

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum Ellen Yeh1*, Joseph L. DeRisi2,3* 1Department of Pathology, Stanford Medical School, Stanford, California, United States of America, 2Department of Biochemistry and Biophysics, University of California,


Plasmodium parasites have a complex life cycle that consists of other proliferative stages in the liver and the mosquito mid-gut. Nothing is known about organellar divi-sion and segregation in these cells, and very little is known about the general appearance of mitochondria in any of the other life stages. As will become apparent during this

Measurement and evaluation of the grinding bodies motions in

8 Organelle segregation into Plasmodium liver stage merozoites Stanway RR, Mueller N, Zobiak B, Graewe S, Froehlke U, Zessin PJ, Aepfelbacher M, Heussler VT. Cell Microbiol. 2011 Nov; 13 (11): 1768-82. doi: 10.1111/j.1462-5822.2011.01657.x. Book contributions 1 Regulation of HIV-1 splicing

Malaria, sexual development and transmission: retrospect and

into the 1980s when P.C.C. Garnham, the joint discoverer of the liver stages, promoted a successful international effort to search for the elusive relapse form of P. vivax, now termed the hypnozoite (see Krotoski, 1985). Likewise, the enigmatic journey of the sporozoite from the skin to liver provoked widespread microscopic and physiological

A bacterial chaperone is required for plastid function in

PfClpC inhibition interferes with the ability of the schizont-stage parasites to properly sort functional apicoplast organelles into daughter-merozoites. These data show that PfClpC is an essential gene that functions to maintain apicoplast integrity. aCC-BY 4.0 International license.

Organelle segregation into Plasmodium liver stage merozoites

Organelle segregation into Plasmodium liver stage merozoites Rebecca R. Stanway,1,2* Nancy Mueller,1 Bernd Zobiak,3 Stefanie Graewe,1 Ulrike Froehlke,1 Patrick J. M. Zessin,1 Martin Aepfelbacher3 and Volker T. Heussler1,2 1Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany.